Hotels in San Cosme y Damian

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Tonight
May 25 - May 26
Tomorrow
May 26 - May 27
Next weekend
May 30 - Jun 1
In two weeks
Jun 6 - Jun 8

Where to stay in San Cosme y Damian?

Top landmarks in San Cosme y Damian

Buenaventura Suarez Planetarium

You can spend time browsing the exhibits at Buenaventura Suarez Planetarium during your travels in San Cosme y Damian. Take in the museums while you're in the area.

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Buenaventura Suarez Planetarium

Guarani Jesuit Ruins of San Cosme and San Damián

Find out about the history of San Cosme y Damian when you take a trip to Guarani Jesuit Ruins of San Cosme and San Damián. Take in the museums while you're in the area.

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Guarani Jesuit Ruins of San Cosme and San Damián

Learn more about San Cosme y Damian

San Cosme y Damian is well-known for its attractions such as Buenaventura Suarez Planetarium and Guarani Jesuit Ruins of San Cosme and San Damián.

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A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

Can I book a refundable hotel in San Cosme y Damian?
If you’re looking for the flexibility to change your plans to San Cosme y Damian, most hotels offer refundable* bookable rates. You can see these properties by searching our site and using the “fully refundable” filter to narrow down the results.
What will the weather in San Cosme y Damian be like during my trip?
January and February are typically the warmest months in San Cosme y Damian when the average temp is 80°F. July and June are the coldest months when the average temperature is 62°F. October and November are the months with the most rain.
Why should I book my San Cosme y Damian hotel with Hotels.com?
There are plenty of reasons to book your San Cosme y Damian travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

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