Photo by Caroline Nunez

Hotels in Mayesville

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Check prices for these dates

Tonight
Apr 25 - Apr 26
Tomorrow
Apr 26 - Apr 27
This weekend
Apr 25 - Apr 27
Next weekend
May 2 - May 4

Where to stay in Mayesville?

1912 Bed and Breakfast
Front of property

1912 Bed and Breakfast

3.5 star property
10.0 out of 10, Exceptional, (260)
The price is $138
includes taxes & fees
$138 per night
May 5 - May 6
1912 Bed and Breakfast
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Mayesville

The region around Mayesville is home to attractions such as Crystal Lakes Golf Course and O'Donnell House.

See all hotels in Mayesville
Somewhere in rural South Carolina off a back road to my hometown. Saw the sunflower field and had to stop.
Photo by Caroline Nunez
Open Photo by Caroline Nunez
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

What hotels do travelers like in Mayesville?
Guests like Hyatt Place Sumter / Downtown, Super 8 by Wyndham Sumter and 1912 Bed and Breakfast.
Can I book a refundable accommodation in Mayesville?
If you need the flexibility to change your travel plans to Mayesville, most hotels offer refundable* bookable rates. You can find these properties by searching our site and using the “fully refundable” filter to narrow the results down.
What will the weather in Mayesville be like during my vacation?
July and August are typically the warmest months in Mayesville when the average temp is 79°F. January and February are the coldest months when the average temperature is 50°F. August and July are the months with the most rain.
Why should I book my Mayesville hotel through Hotels.com?
There are lots of reasons to book your Mayesville trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

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